This is commonly observed error on Plesk based windows FTP service while connecting remotely. Locally you can easily connect to FTP, but remotely it will show "Home directory inaccessible" error.
You can for following solution on this error,a. Repair permissions on home folders of problem domains.
b. Re-configure FTP configuration using Plesk command line tool ftpmng.exe as follows:
Login to RDP of the server, open command prompt, navigate to %plesk_bin% directory. Execute following commands,
ftpmng.exe --remove-vhost --vhost-name=yourdomain.com
ftpmng.exe --reconfigure-vhost --vhost-name=yourdomain.com
c. If this issue happens to every domain you can repair FTP configuration for all domains using commands as below:
Login to RDP of the server, open command prompt, navigate to %plesk_bin% directory. Execute following commands,
ftpmng.exe --remove-all
ftpmng.exe --reconfigure-all